IFNγ和IL-6对人肝癌细胞系C1抑制物合成的调控

IFNγ和IL-6对人肝癌细胞系C1抑制物合成的调控

免疫学杂志 2000年第2期第16卷 基础免疫学

作者：陈晓韧 谢佩蓉 郑 萍

单位：第三军医大学免疫学教研室，重庆 400038

关键词：C1抑制物；肝癌细胞系；IFNγ；IL-6

摘 要：目的为研究IFNY或IL-6对肝癌细胞系C1抑制物(C1INH)合成的调控作用。方法用ELISA双夹心法检测了经其刺激后HepG2和SMMC7712细胞培养上清中C1lNH的含量。结果两细胞系自身能合成少量C1INH。IFNγ和IL-6可通过不同的途径上调两种细胞C1INH的合成，且IFNγ的作用强于IL-6。结论此结果提示有可能用IFNγ和IL-6治疗C1LNB缺乏病。

分类号：R392.11文献标识码：A

文章编号：1000-8861(2000)02-0084-04

作者简介：陈晓韧(1970-)，女，四川乐山市人，主治医师，硕士，主要从事分子免疫学研究，现在空军总医院检验科工作。参考文献：

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收稿日期：1999-05-10